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NSC 65809
CAS No. 94023-67-3
NSC 65809 ( 3-[(2,3-dichlorophenyl)methylene]carbazamidine )
产品货号. M22219 CAS No. 94023-67-3
Raphin1 是 R15B 的选择性抑制剂。在细胞中，Raphin1 会导致其磷酸化底物快速、瞬时积累，从而导致蛋白质合成瞬时减弱。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1604 | 有现货 |
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| 5MG | ￥2414 | 有现货 |
|
| 10MG | ￥3669 | 有现货 |
|
| 25MG | ￥6051 | 有现货 |
|
| 50MG | ￥8505 | 有现货 |
|
| 100MG | ￥11502 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称NSC 65809
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Raphin1 是 R15B 的选择性抑制剂。在细胞中，Raphin1 会导致其磷酸化底物快速、瞬时积累，从而导致蛋白质合成瞬时减弱。
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产品描述Raphin1 is a selective inhibitor of R15B.In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis. In vitro, Raphin1 inhibits the recombinant R15B-PP1c holoenzyme, but not the closely related R15A-PP1c, by interfering with substrate recruitmentRaphin1 was orally bioavailable, crossed the blood-brain barrier, and demonstrated efficacy in a mouse model of Huntington's disease.
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体外实验——
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体内实验——
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同义词3-[(2,3-dichlorophenyl)methylene]carbazamidine
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通路Others
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靶点Other Targets
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受体R15B
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研究领域——
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适应症——
化学信息
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CAS Number94023-67-3
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分子量231.08
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分子式C8H8Cl2N4
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纯度>98% (HPLC)
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溶解度——
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SMILESNC(=N)N/N=C/c1cccc([Cl])c1[Cl]
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Agnieszka Krzyzosiak, Anna Sigurdardottir, Laura Luh.et al.Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B.Cell. 2018 Aug 23;174(5):1216-1228.e19.
产品手册
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